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Cellectar and NorthStar Partner to Advance Radiotherapy Development

Cellectar partners with NorthStar for Ac-225 supply, advancing CLR 121225 radiotherapy toward clinical trials.

Mrudula Kulkarni
By Mrudula Kulkarni
Managing Editor - Pharma Now
Nov 15, 2024Updated Jun 26, 2025 · 2 min read
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Cellectar and NorthStar Partner to Advance Radiotherapy Development
https://crukcambridgecentre.org.uk/patient-care/clinical-research/radiotherapy
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Reviewed by Mrudula Kulkarni, Managing Editor - Pharma Now

Cellectar Biosciences has entered a 10-year agreement with NorthStar Medical Radioisotopes for a steady supply of non-carrier-added Actinium-225 (Ac-225), a rare and critical isotope for its CLR 121225 radiotherapeutic program. CLR 121225, which uses Cellectar’s Phospholipid Ether (PLE) delivery platform, has shown promise in preclinical studies targeting pancreatic and triple-negative breast cancers, among others.

This partnership addresses the limited global supply of Ac-225, enabling the progression of CLR 121225 to human clinical trials in 2025. The collaboration underlines a commitment to advancing alpha-emitting radiotherapies.

NorthStar’s expertise in producing high-purity Ac-225 ensures reliable support for Cellectar’s innovative therapeutic approach, which aims to bring first-in-class cancer treatments to market.

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Mrudula Kulkarni
Written by
Mrudula Kulkarni
Managing Editor - Pharma Now

My international experience as a researcher in Taiwan for three years has equipped me with a global perspective, enabling me to create content that resonates with an international audience.



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