Astria's ALPHA-STAR Trial Breakthrough

Astria Therapeutics has announced positive results from its ALPHA-STAR Phase 1b/2 trial evaluating navenibart (STAR-0215) for hereditary angioedema (HAE). The trial showed a 90-95% reduction in monthly attack rates over six months, with no serious adverse events and favorable tolerability. Results support three- and six-month dosing schedules.

Astria plans to initiate Phase 3 development in Q1 2025, with topline results expected by late 2026. All patients have joined an ongoing long-term trial to evaluate safety and efficacy further, with interim data expected mid-2025.