PacBio And Chulalongkorn Launch Thailand’s First Newborn Genome Sequencing

PacBio and Chulalongkorn University have launched a strategic collaboration to implement HiFi whole-genome sequencing (WGS) as part of Thailand's newborn screening research program. This initiative is the first of its kind in Asia Pacific to explore PacBio’s long-read sequencing technology at a population scale, aiming to improve the early detection of rare and treatable genetic conditions. The program marks a significant step toward modernising newborn screening by replacing limited targeted panels with more comprehensive genomic assessments.

“Our shared goal is to establish a robust and scalable research model for genomic newborn screening that helps uncover the genetic basis of undiagnosed conditions from birth. We are excited to work with PacBio to bring this vision closer to reality for families in Thailand,” said Professor Vorasuk Shotelersuk from the Centre of Excellence for Medical Genomics, Chulalongkorn University, Thailand. 

PacBio’s HiFi WGS provides highly accurate, long-read data that captures structural variants, repeat expansions, and epigenomic marker regions often missed by short-read sequencing methods. This enables researchers to uncover a broader spectrum of genetic risk factors at birth. The collaboration is designed to enhance early diagnosis and treatment of rare diseases and establish new benchmarks in genomic research and precision medicine.

“Every child deserves the best possible start to life, and that begins with giving families and clinicians access to comprehensive genomic information from the beginning,” said Christian Henry, President and Chief Executive Officer of PacBio. “This collaboration demonstrates how advanced sequencing technologies like HiFi can enable broader insights at birth. It’s deeply aligned with our mission at PacBio to make high-quality genomic information accessible where it’s needed most, and we’re proud to support Chulalongkorn University and Thailand as they lead the way in laying the foundation for a new model of care.”

With this effort, Thailand is positioning itself as a leader in population-scale genomics in the Asia Pacific region. The project reinforces Thailand’s public health infrastructure and its commitment to translational research. It could serve as a model for other nations aiming to implement genome-wide approaches in newborn screening, advancing data-sharing capabilities and international collaboration in equitable genomic healthcare.